Approving a vaccine that is utilizing novel RNA technology without extensive testing is
extremely dangerous. The vaccine could be more dangerous than the original infection.
Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARSCoV-
2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In
this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine
recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the
potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma
(FUS) into their pathologic prion conformations. The results indicate that the vaccine RNA has specific sequences
that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total
of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two
GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated
computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine
RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential
to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic
prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause
ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The
enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the
RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.
